Wholly Owned Pipeline

PureTech's Wholly Owned Programs are designed to enhance on-target efficacy, enable oral administration or improve tolerability to unlock new classes of medicine that have been held back by one of these issues.

Wholly Owned Pipeline

Our programs1
Discovery
Preclinical
Phase 1
Phase 2
Phase 3
LYT-100
Deupirfenidone
Idiopathic pulmonary fibrosis (IPF)

2

IPF

~3M worldwide


Therapeutic candidate being advanced for the potential treatment of conditions involving inflammation and fibrosis, including idiopathic pulmonary fibrosis (IPF). We are also exploring the potential evaluation of LYT-100 in radiation induced fibrosis, myocardial fibrosis and other organ system fibrosis based on the strength of existing data around the use of pirfenidone in these indications.

LYT-100
Deupirfenidone
Exploring additional indications (e.g., radiation induced fibrosis, myocardial fibrosis, other organ system fibrosis and lymphedema)

1

Exploring additional indications (e.g., radiation induced fibrosis, myocardial fibrosis, other organ system fibrosis and lymphedema)

Therapeutic candidate being advanced for the potential treatment of conditions involving inflammation and fibrosis, including idiopathic pulmonary fibrosis (IPF). We are also exploring the potential evaluation of LYT-100 in radiation induced fibrosis, myocardial fibrosis and other organ system fibrosis based on the strength of existing data around the use of pirfenidone in these indications.

LYT-200
Anti-Galectin-9 MAb
Solid tumors and hematological malignancies

1

Solid tumors

>32K/year U.S. (Metastatic pancreatic cancer)
>33K/year U.S. (Metastatic CRC)
>4K/year U.S. (Metastatic cholangiocarcinoma)


Fully human monoclonal antibody designed to inhibit the activity of galectin-9, a key molecule expressed by tumors and immune cells and shown to suppress the immune system from recognizing and destroying cancer cells, which we are developing for difficult-to-treat cancer indications with poor survival rates, including pancreatic ductal adenocarcinoma (PDAC), colorectal cancer (CRC) and cholangiocarcinoma (CCA).

LYT-300
Oral Allopregnanolone
Depression, anxiety & related indications

1

Depression, anxiety & related indications

Designed to unlock the validated efficacy of allopregnanolone to potentially offer a new, oral treatment option for a range of conditions where there is significant patient need. Allopregnanolone, a positive allosteric modulator of GABAA receptors, has therapeutic potential across a wide range of neurological conditions like depression, epilepsy and other neurological and neuropsychological conditions, but has poor oral bioavailability as a result of first-pass liver metabolism. An intravenous formulation of allopregnanolone is approved by the FDA as a 60-hour infusion for the treatment of post-partum depression, though the method of administration has significant limitations.

LYT-310
Oral Cannabidiol
Epilepsies & other neurological indications

Preclinical

Epilepsies & other neurological indications

Therapeutic candidate designed to unlock the validated efficacy of cannabidiol (CBD). Derived from the Glyph platform, LYT-310 offers oral dosing and the potential for improved tolerability, which could expand the therapeutic application of CBD across a wider range of age groups and indications, including both rare and more common forms of epilepsy and other central nervous system disorders.

Phase completedPhase in progress

Preclinical, Research and Partnered Programs

LYT-510 (Oral Immunosuppressant)
LYT-503 / IMB-150 (Partnered Program)

Developing breakthrough medicines at PureTech

Collaborative drug discovery based on proprietary biological insights
Rapid & cost-efficient prioritization & validation
Develop internally, partner or spin-out
Collaborative drug discovery based on proprietary biological insights
Rapid & cost-efficient prioritization & validation
Develop internally, partner or spin-out