Wholly Owned Pipeline

PureTech's Wholly Owned Programs are designed to harness key immunological, fibrotic and lymphatic system mechanisms. These novel classes of immunomodulatory drugs are designed to treat serious diseases, including lung dysfunction, immuno-oncology, lymphatic, neurological and neuropsychological disorders.

Wholly Owned Pipeline

Our programs1
Discovery
Preclinical
Phase 1
Phase 2
Phase 3
LYT-100-ILD
Deupirfenidone
IPF & potentially other PF-ILDs

2

IPF & potentially other progressive fibrosing ILDs

~200K U.S. (PF-ILDs, including IPF) 


Therapeutic candidate being advanced for the potential treatment of conditions involving inflammation and fibrosis, including lung disease (e.g., idiopathic pulmonary fibrosis (IPF) and potentially other progressive fibrosing interstitial lung diseases (PF-ILDs) and Long COVID respiratory complications and related sequelae), and disorders of lymphatic flow, such as lymphedema.

LYT-100-COV
Deupirfenidone
Long COVID2 respiratory complications & related sequelae

2

Long COVID respiratory complications & related sequelae

>150M Worldwide

Therapeutic candidate being advanced for the potential treatment of conditions involving inflammation and fibrosis, including lung disease (e.g., idiopathic pulmonary fibrosis (IPF) and potentially other progressive fibrosing interstitial lung diseases (PF-ILDs) and Long COVID respiratory complications and related sequelae), and disorders of lymphatic flow, such as lymphedema.
LYT-100-LYMPH
Deupirfenidone
Lymphatic flow disorders, including lymphedema

2a

Lymphatic flow disorders, including lymphedema

~1M U.S.

Therapeutic candidate being advanced for the potential treatment of conditions involving inflammation and fibrosis, including lung disease (e.g., idiopathic pulmonary fibrosis (IPF) and potentially other progressive fibrosing interstitial lung diseases (PF-ILDs) and Long COVID respiratory complications and related sequelae), and disorders of lymphatic flow, such as lymphedema.
LYT-200
Anti-Galectin-9 MAb
Solid tumors

1

Solid tumors

>50K/year U.S. (Metastatic CRC)
>28K/year U.S. (Metastatic pancreatic cancer)
>4K/year U.S. (Metastatic cholangiocarcinoma)


Fully human monoclonal antibody designed to inhibit the activity of galectin-9, a key molecule expressed by tumors and immune cells and shown to suppress the immune system from recognizing and destroying cancer cells, which we are developing for difficult-to-treat cancer indications with poor survival rates, including pancreatic ductal adenocarcinoma (PDAC), colorectal cancer (CRC) and cholangiocarcinoma (CCA).

LYT-210
Anti-Delta-1 MAb
Solid tumors

Preclinical

Solid tumors

>50K/year U.S. (Metastatic CRC)
>28K/year U.S. (Metastatic pancreatic cancer)
>4K/year U.S. (Metastatic cholangiocarcinoma)


Fully human IgG1 monoclonal antibody directed against the delta-1 chain of T cells bearing gamma delta-1 T cell receptors that we have designed to target and deplete immunosuppressive gamma delta-1 T cells in cancer.

LYT-300
Oral Allopregnanolone
Neurological indications

Preclinical

Neurological indications

Oral form of allopregnanolone, a natural neurosteroid, that we believe may be applicable to a range of neurological conditions. An IV version of allopregnanolone, also known as brexanolone, is approved by the FDA to treat postpartum depression.
LYT-500
Oral IL-22 +
Anti-inflammatory
IBD

Preclinical

Inflammatory bowel disease

~3M U.S.

Therapeutic candidate being advanced for the potential treatment of inflammatory bowel disease (IBD) that is designed with a dual mechanism of action to provide both mucosal repair and targeted resolution of tissue inflammation.
LYT-503/IMB-150
(Imbrium collaboration) Non-opioid
IC/BPS

Preclinical

Interstitial cystitis/Bladder pain syndrome

~4-12M U.S.

Therapeutic candidate being developed for the potential treatment of interstitial cystitis/bladder pain syndrome (IC/BPS) that is designed to selectively treat IC/BPS while minimizing the potential for related systemic toxicities by selectively targeting API pharmacology to inflamed tissue.
Phase completedPhase in progressRegistration-enabling studies planned

1 The FDA and corresponding regulatory authorities will ultimately review our clinical results and determine whether our wholly-owned therapeutic candidates are safe and effective. No regulatory agency has made any such determination that our wholly-owned therapeutic candidates are safe or effective for use by the general public for any indication.
2 Long COVID is a term being used to describe the emerging and persistent complications following the resolution of COVID-19 infection, also known as post-acute COVID-19 syndrome (PACS). 

The BIG Idea - Moving medicine forward at PureTech

Collaborative drug discovery based on proprietary biological insights
Rapid & cost-efficient prioritization & validation
Develop internally, partner or spin-out
Collaborative drug discovery based on proprietary biological insights
Rapid & cost-efficient prioritization & validation
Develop internally, partner or spin-out

Relationships with leading pharma companies or their investment arms