All of the underlying programs and platforms across PureTech's Founded Entities were initially identified or discovered and then advanced by its team through key validation points before being further developed by each respective Founded Entity.
All of the underlying programs and platforms across PureTech's Founded Entities were initially identified or discovered and then advanced by its team through key validation points before being further developed by each respective Founded Entity.
$3.7B2
Investments and Non-Dilutive Funding Raised by Founded Entities Since January 2018 

Advancing transformative medicines for people living with psychiatric and neurological conditions

2.8% Equity plus Milestone Payments/ 20% Sublicense Revenue/ Royalties & up to $500M from agreement w/Royalty Pharma3
PHASE 3

Pioneering the development of cognitive treatments through game-changing technologies

14.6% Equity
COMMERCIAL

Advancing a novel category of treatments for weight management and gut related chronic diseases

22.8% Equity plus Royalties4
COMMERCIAL

Engineering hematopoietic stem cells to enable targeted therapies post-transplant

4.0% Equity
PHASE 1/2a

Pioneering a new category of oral therapies based on defined bacterial consortia

40.8% Equity5
PHASE 3 READY

Developing a voice-based technology platform to detect changes of health conditions

36.5% Equity
COMMERCIAL RELEASE

Engineering hydrogels to enable the oral administration of biologics

73.8% Equity
PRECLINICAL
Note: This figure represents the stage of development for each Founded Entity’s most advanced therapeutic candidate. While PureTech maintains ownership of equity interests in its Founded Entities, the Company does not, in all cases, maintain control over these entities (by virtue of (i) majority voting control and (ii) the right to elect representation to the entities' board of directors) or direct the management and development efforts for these entities. Consequently, not all such entities are consolidated in the financial statements. Where PureTech maintains control, the entity is referred to as a Controlled Founded Entity in this report and is consolidated in the financial statements. Where PureTech does not maintain control, the entity is referred to as a Non-Controlled Founded Entity and is not consolidated in the financial statements. As of December 30, 2022, Controlled Founded Entities include Vedanta Biosciences, Inc. and Non-Controlled Founded Entities include Gelesis Holdings, Inc., Karuna Therapeutics, Inc., Akili, Inc., Sonde Health, Inc. and Vor Biopharma Inc. Relevant ownership interests for Founded Entities were calculated on a partially diluted basis (as opposed to a voting basis) as of December 15, 2022, including outstanding shares, options and warrants, but excluding unallocated shares authorized to be issued pursuant to equity incentive plans. Gelesis, Vor Bio, Akili and Karuna ownerships were calculated on a beneficial ownership basis in accordance with SEC rules as of May 12, 2023, May 5, 2023, May 5, 2023, and April 24, 2023, respectively. With the exception of Plenity® and EndeavorRx®, candidates are investigational and have not been cleared by the FDA for use in the U.S.
2 Funding figure can include private equity financings, loans and promissory notes, public offerings or grant awards, and gross proceeds from SPAC mergers. Funding figure excludes future milestone considerations received in conjunction with partnerships and collaborations.
3 As of March 22, 2023, PureTech has sold its right to receive a 3% royalty from Karuna to Royalty Pharma on net sales up to $2 billion annually, after which threshold PureTech will receive 67% of the royalty payments and Royalty Pharma will receive 33%. PureTech retains its equity ownership in Karuna. Additionally, under its license agreement with Karuna, PureTech retains the right to receive milestone payments upon the achievement of certain regulatory approvals and 20% of sublicense income.
4Represents the percentage of Gelesis’ outstanding common stock held by PureTech as of May 12, 2023. On a beneficial ownership basis (as calculated in accordance with SEC rules), PureTech owns 88.4% of the outstanding share capital of Gelesis as of May 26, 2023. On April 27, 2023, PureTech submitted a non-binding proposal to acquire all of the outstanding equity and equity-linked securities of Gelesis. Please see PureTech’s Schedule 13D filings with respect to Gelesis on file with SEC for additional information. PureTech is also eligible to receive certain payments from Gelesis under its license agreement, including sublicense payments and royalties on sales of certain products, including Plenity.
5As of December 31, 2022, PureTech’s percentage ownership of Vedanta Biosciences was approximately 40.8% on a partially diluted basis. This calculation includes outstanding shares, options, and warrants, but excludes unallocated shares authorized to be issued pursuant to equity incentive plans. Vedanta’s $106.5 million recent financing round was structured as convertible debt. PureTech ownership reflects current ownership and does not take into account any potential future dilution, if applicable, as a result of conversion of that debt amount.

Developing breakthrough medicines at PureTech