Building the biopharma company of the future

Developing New Categories of Medicine

Our goal is to improve and extend the lives of patients through the development of new categories of medicine

Exploring the Brain Immune Gut (BIG) Axis

Focused on the crosstalk and biological processes associated with the brain-immune-gut interface

Giving Life to Science

Our goal is to improve and extend the lives of patients


Moving Medicine Forward


Discovery Reinvented

Publications
Publications -2017-09-19
Gamma Delta T Cells Support Pancreatic Oncogenesis by Restraining αβ T Cell Activation

CD4(+) T regulatory cells (T(regs)), which express the Foxp3 transcription factor, play a critical role in the maintenance of immune homeostasis. Here, we show that in mice, T(regs) were most abundant in the colonic mucosa.

Full Article

Publications -2017-09-19
The Gut’s Clostridium Cocktail

Specific components of the microbiota—the microorganisms that normally colonize the body—can affect disease progression in mouse models of arthritis, central nervous system inflammation, diabetes, intestinal inflammation, and obesity.

Full Article
Publications -2017-06-01
Video game training enhances cognitive control in older adults

Cognitive controlis defined by a set of neural processes that allow us to interact with our complex environment in a goal-directed manner.

FULL ARTICLE

Events
2017-10-23
PureTech’s Jim Harper Presents on Sonde Health and Affective Computing in Action at ACII 2017 in San Antonio, TX

The Association for the Advancement of Affective Computing will host its seventh International Conference on Affective Computing and Intelligent Interaction (ACII2017), which will be held in San Antonio, Texas on October 23-26, 2017.

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Publications
2017-10-20
Intestinal inflammation induced by oral bacteria

Numerous microorganisms, including bacteria, colonize the intestine where they play important roles in maintaining homeostasis. However, commensal bacteria with pathogenic potential, such as Helicobacter hepaticus, can also induce intestinal inflammation. Cross-talk between gut microbiota and the host immune system can prevent or mediate chronic intestinal inflammation, the outcome of which depends on gut microbiota composition, immune response, host genetic factors, and how these factors interact (12). 

FULL ARTICLE

Media Coverage
2017-10-11
Six Grand Ideas to Fight the End of Antibiotics

Overuse of antibiotics has led them to becoming less and less effective to treat us when we’re sick – leaving scientists scrambling for a fix. Here are some of the best ideas to tackle one of the 21st Century's biggest challenges.

FULL ARTICLE