Meningeal Lymphatics Platform

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Meningeal Lymphatics Platform

A platform that aims to correct lymphatic dysfunction in the brain to potentially improve outcomes for a range of neurodegenerative and neuroinflammatory conditions that are not currently effectively treated, such as Alzheimer’s disease and Parkinson’s disease.

Phase completedPhase in progress
Altering lymphatic flow, both in the CNS and other parts of the body

The lymphatic system is an important part of the immune system, GI system and central nervous system (CNS), and loss of lymphatic flow can play a critical role in diseases of these systems. This concept underlies PureTech’s meningeal lymphatics platform, which aims to correct lymphatic dysfunction in the brain to potentially improve outcomes for a range of neurodegenerative and neuroinflammatory conditions that are not currently effectively treated, such as Alzheimer’s disease (AD) and Parkinson’s disease. 

We are advancing a broad pipeline of programs to treat cognitive deficiency and improve symptoms associated with medical conditions across neurology and psychiatry, including attention-deficit hyperactivity disorder (ADHD), major depressive disorder (MDD), autism spectrum disorder (ASD), multiple sclerosis (MS) and various other neuroinflammatory diseases. We are also developing associated clinical monitors and measurement-based care applications. Our lead, patented technology platform is exclusively licensed from the lab of Dr. Adam Gazzaley at the University of California, San Francisco (UCSF), and augmented by proprietary adaptive algorithms developed by our team.

  • Innovative Approach for Solving the Problem
    • The meningeal lymphatics is a functional lymphatic system in the meninges of the brain that was recently discovered by one of PureTech’s collaborators, Jonathan Kipnis, PhD, a professor at the University of Virginia. These meningeal lymphatics have been described as the “brain drain,” a route through which macromolecules are flushed from the brain in cerebrospinal fluid. Among the macromolecules that are drained via the lymphatics are pathogenic macromolecules such as amyloid-beta and tau, which are both associated with AD pathology, as well as alpha-synuclein, which is associated with Parkinson’s disease. In animal models of AD, AD associated tauopathies and Parkinson’s disease, blocking meningeal lymphatic flow significantly exacerbated disease progression and severity, and improving flow through aged meningeal lymphatics improved cognitive brain function in these animal models. With aging, the lymphatic vessels that drain the brain become dysfunctional and no longer drain as efficiently. The “lymphedematous characteristics” of meningeal lymphatic vessels in aged animals might be leading to inefficient clearance of pathologic macromolecules and potentially increase risk for neurodegenerative diseases. PureTech is exploring multiple ways of altering lymphatic flow, both in the CNS and other parts of the body. Starting with LYT-100, PureTech is developing novel therapeutic candidates that target inflammation, fibrosis and other mechanisms that impair lymphatic flow.
  • Intellectual Property

    PureTech has broad intellectual property coverage around its meningeal lymphatics platform, which includes exclusively licensed patent applications covering compositions of matter, methods of use and methods of treatment encompassing its platform-based brain lymphatic technologies, including the identification of macromolecular targets, as well as various classes of brain lymphatic targeting therapeutics for use in the treatment of a wide range of neurodegenerative and neuroinflammatory conditions, as well as various neuropathies and cancers. As of 31 December 2019, PureTech’s brain lymphatics patent portfolio consists of eight patent families comprising seven U.S. patent applications, two international PCT applications and five foreign patent applications exclusively licensed from the University of Virginia Licensing & Ventures Group. Any issued patents from the in-licensed patent applications are expected to expire in 2037 through 2040, exclusive of possible patent term adjustments or extensions or other forms of exclusivity.


Meningeal Lymphatics Platform