Utilizing the recently described brain lymphatic network to target neurodegenerative and CNS autoimmune diseases

CNS Lymphatics Technology

Emerging evidence suggests that the lymphatic system may play a critical role in the health of the central nervous system (CNS). The recently discovered association between the meningeal lymphatic system with the CNS shed new light on the previously accepted rules of human biology, such as CNS immune privilege. 

  • Collaborations
    • This approach is based on the work of Jonathan Kipnis, Ph.D., Harrison Distinguished Teaching Professor and Chair, Department of Neuroscience, and Director, Center for Brain Immunology and Glia, at the University of Virginia School of Medicine

    • In 2015, Dr. Kipnis published his original discovery of lymphatic vessels in the brain in Nature. Building on that discovery, Dr Kipnis’ latest publication in the July 25, 2018 issue of Nature reveals the potential role of these lymphatic vessels, including Alzheimer’s disease, Huntington’s disease, and age-associated cognitive decline. The publication presents preclinical models that suggest modulation of lymphatic function in the brain may prevent or delay diseases associated with neurodegeneration

 

These insights around the CNS-immune interface underlie our approach to designing novel categories of therapeutics to address debilitating and devastating CNS disorders.