PureTech Health News
Publications
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Publications -2018-03-23
PureTech's Lymphatic Leap

PureTech Health plc is launching a new branch of inquiry into the lymphatic system following discoveries that the network extends into the brain and could be used to deliver immunotherapies directly to tissues.

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Publications -2017-09-19
Gamma Delta T Cells Support Pancreatic Oncogenesis by Restraining αβ T Cell Activation

CD4(+) T regulatory cells (T(regs)), which express the Foxp3 transcription factor, play a critical role in the maintenance of immune homeostasis. Here, we show that in mice, T(regs) were most abundant in the colonic mucosa.

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Publications -2017-09-19
The Gut’s Clostridium Cocktail

Specific components of the microbiota—the microorganisms that normally colonize the body—can affect disease progression in mouse models of arthritis, central nervous system inflammation, diabetes, intestinal inflammation, and obesity.

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Press Releases
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Press Release - 2018-06-19
Karuna
PureTech’s Karuna Receives $8 Million Wellcome Trust Award to Advance Phase 2 Product Candidate for the Treatment of Schizophrenia
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Media Coverage
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Media Coverage - 2018-04-10
PureTech Health spin-outs Akili and Sonde Health announce new international patents

This week has spurred some major patent announcements from digital health companies Akili Interactive and Sonde Health, which are both affiliated with PureTech Health, a cross disciplinary biopharma company.

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Events
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Events - 2018-03-12
PureTech Health CEO Daphne Zohar to Present at The Wall Street Journal Health Forum on May 22, 2018 in Washington, D.C.
Publications
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Publications - 2018-04-04
Towards an arthritis flare-responsive drug delivery system

Local delivery of therapeutics for the treatment of inflammatory arthritis (IA) is limited by short intra-articular half-lives. Since IA severity often fluctuates over time, a local drug delivery method that titrates drug release to arthritis activity would represent an attractive paradigm in IA therapy. Here we report the development of a hydrogel platform that exhibits disassembly and drug release controlled by the concentration of enzymes expressed during arthritis flares. 

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Latest Science: Brain-Immune-Gut Axis
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Latest Science: Brain-Immune-Gut Axis - 2017-11-21
Sympathetic neuron–associated macrophages contribute to obesity by importing and metabolizing norepinephrine, Nature Medicine

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Exploring the Brain Immune Gut Interface

Targeting serious diseases caused by dysfunctions in the brain-immune-gut axis

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