PureTech Health News
Publications
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Publications -2017-09-19
Gamma Delta T Cells Support Pancreatic Oncogenesis by Restraining αβ T Cell Activation

CD4(+) T regulatory cells (T(regs)), which express the Foxp3 transcription factor, play a critical role in the maintenance of immune homeostasis. Here, we show that in mice, T(regs) were most abundant in the colonic mucosa.

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Publications -2017-09-19
The Gut’s Clostridium Cocktail

Specific components of the microbiota—the microorganisms that normally colonize the body—can affect disease progression in mouse models of arthritis, central nervous system inflammation, diabetes, intestinal inflammation, and obesity.

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Publications -2017-06-01
Video game training enhances cognitive control in older adults

Cognitive controlis defined by a set of neural processes that allow us to interact with our complex environment in a goal-directed manner.

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Press Releases
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Press Release - 2017-11-20
Selective mTORC1 Inhibitors
PureTech’s resTORbio Advances Immunotherapy Candidate for Aging-Related Conditions Following Recommendation from Independent Data Monitoring Committee

PureTech Health plc (LSE: PRTC), an advanced, clinical-stage biopharmaceutical company, announced today that resTORbio, Inc., an affiliate of PureTech Health, has begun dosing patients in the second part of a Phase 2b clinical study designed to assess the safety, tolerability and efficacy of resTORbio’s lead programme in reducing respiratory tract infections (RTIs) in the elderly.

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Media Coverage
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Media Coverage - 2017-11-08
Don't Have a Chief Innovation Officer? Get One...Now

Chief innovation officers (CInOs) are poised to become one of the more important executives in the C-suite in pharma just as they are in other industries. As the scope and pace of changes facing the life sciences industry accelerate, innovation must occur faster — not just in R&D but throughout the organization. Achieving fast, focused innovation, however, often requires thinking outside the usual silos and chains of command to foster — and manage — innovation in unusual ways.

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Events
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Events - 2017-11-17
PureTech’s CEO Daphne Zohar to present in keynote session at CNS Summit 2017 on November 17, 2017, plus Akili’s Eddie Martucci and Adam Gazzaley also to present at conference
Publications
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Publications - 2017-10-20
Microbiome-Derived Immune Modulators
Intestinal inflammation induced by oral bacteria

Numerous microorganisms, including bacteria, colonize the intestine where they play important roles in maintaining homeostasis. However, commensal bacteria with pathogenic potential, such as Helicobacter hepaticus, can also induce intestinal inflammation. Cross-talk between gut microbiota and the host immune system can prevent or mediate chronic intestinal inflammation, the outcome of which depends on gut microbiota composition, immune response, host genetic factors, and how these factors interact (12). 

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Latest Science: Brain-Immune-Gut Axis
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Latest Science: Brain-Immune-Gut Axis - 2017-10-19
A Spoonful of Sugar Could be the Medicine, Nature Magazine

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Exploring the Brain Immune Gut Interface

Targeting serious diseases caused by dysfunctions in the brain-immune-gut axis

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